Certain soluble peptide and protein, under specific conditions, can aggregate into insoluble forms, which contributes to pathological conditions (Chiti & Dobson, 2006). The formation of Abeta plagues, a landmark of AD, is a result of the cleavage of Amyloid precursor protein (APP).
APP, plays important developmental roles (Loffler & Huber, 1992). In adult brain, the expression of APP seems to associate with cell injury (Graham et al., 1996)
|Involvement in Alzheimer's disease|
|Abeta is the major constitute of amyloid aggregates. To form Abeta, APP is sequentially cleavaged by proteolytic enzyme beta- and gamma-secretase. Among the many cleavage products, Abeta42 is the one most relevant to the disease.|