Stuart Edelstein

Stuart EdelsteinStuart J. Edelstein received a Ph.D. in Biochemistry from the University of California (Berkeley) in 1967. Following a post-doctoral year at the Pasteur Institute in the laboratory of Jacques Monod, he joined the faculty of Cornell University where he became Professor in 1977 and served as Chairman of the Section of Biochemistry, Molecular and Cell Biology. In 1986 he moved to the University of Geneva, and was director of the Department of Biochemistry until 1994. He returned to the Pasteur Institute in 1994 for a sabbatical leave in the laboratory of Jean-Pierre Changeux, with whom he continues an active collaboration. He held the International Chair at the Collège de France in 2002-03. In 2007 he joined the Computational Neurobiology group led by Nicolas Le Novère at the European Bioinformatics Institute and followed the group when it moved to the Babraham Institute.

Prof. Edelstein research has been dominated by a long-standing interest in cooperative interactions of proteins and their ligands, beginning with oxygen binding and the structure of hemoglobin, and later developing detailed modeling of the kinetics of ligand-gated channels. Recent activities have focused on applying the allosteric principles to more complex systems such as the interactions involving calcium/calmodulin-dependent kinase II and more generally the dynamics of the dendritic spines of neurons. S.J. Edelstein has published over 100 research articles and six books, among which THE SICKLED CELL: FROM MYTHS TO MOLECULES (Harvard University Press, Cambridge, 1986), and NICOTINIC ACETYLCHOLINE RECEPTORS: FROM MOLECULAR BIOLOGY TO COGNITION with Jean-Pierre Changeux (The Johns Hopkins University Press, Baltimore & Odile Jacob Publishing, Paris, 2005).

He served as President of the Swiss Biophysical Section (1994-1998) and President of the Swiss Committee of the International Union for Pure and Applied Biophysics. His other activities include membership in the Scientific Commission, Curie Institute Research Section (Paris), Scientific Director of the major French biotechnology magazine BioFutur, President of the Scientific Advisory Board of Noir&Blanc, an NGO Medical Foundation devoted to treating sickle cell anemia in Africa, 2004-2010.

Amoung other honours, he was elected Foreign Associate of the French Académie des Sciences, and awarded the Légion d'honneur by the French Prime Minister.