Nicolas Gambardella

Nicolas Le NovèreNicolas Gambardella Le Novère studied molecular biology and biochemistry at École Normale Supérieure, evolution at University Paris XI, biophysics and pharmacology at Paris VI. After a PhD thesis on the structure and function of neuronal nicotinic receptors with Jean-Pierre Changeux at the Pasteur Institute, that comprised experimental and bioinformatics analyses, he pursued a post-doctoral training in modelling bacterial chemotaxis with Dennis Bray at the University of Cambridge (UK). At that time, he was privileged to participate to the development of what was becoming a new field in life sciences, systems biology. As group leader at the EMBL-European Bioinformatics Institute, he merged his two main scientific interests, computational systems biology and the study of neuronal function. Besides his research on cellular signalling, he developed resources for systems biology, for instance standards like SBML and SBGN or databases like BioModels Database. Gambardella Le Novère is now director of aSciStance Ltd, a company providing consulting in computational biology and scientific writing. He is also directeur de recherche on leave from the French Centre National de la Recherche Scientifique (CNRS). [ More ][ Blog ][ Google Scholar page ]

2012-present Senior group leader Babraham Institute, Cambrigge, UK
2003-2012 Group leader EMBL-EBI, Cambridge, UK
2001-2003 Research fellow (PI: Jean-Pierre Changeux) CNRS, Paris, FR
1999-2001 Post-doc fellow (PI: Dennis Bray) Universtity of Cambridge, Cambridge, UK
1992-1999 Student, post-doc (PI: Jean-Pierre Changeux) Institut Pasteur, Paris, FR
Five key publications
Le Novère N. et al. The Systems Biology Graphical Notation. Nature Biotechnology (2009), 27: 735-741. pubmed-small.jpg
Le Novère N. et al. BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Research (2006), 34: D689-D691. pubmed-small.jpg
Le Novère N. et al. Minimum Information Requested In the Annotation of biochemical Models (MIRIAM). Nature Biotechnology (2005), 23: 1509-1515. pubmed-small.jpg
Hucka M., et al. The Systems Biology Markup Language (SBML): A Medium for Representation and Exchange of Biochemical Network Models. Bioinformatics (2003), 19: 524-531. pubmed-small.jpg
Le Novère N., et al. Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. European Journal of Neuroscience (1996), 8: 2428-2439. pubmed-small.jpg