AgedBrainSYSBIO is a project funded by the European Commission to unravel the biochemical pathways underlying the synaptic disorders associated with neurodegenerative diseases and in particular Alzheimer disease. The main goals addressed by the consortium will be:
- Identify and reconstruct physical and functional interactomes involved in late onset Alzheimer disease (LOAD) using genome wide association studies (GWAS) and proteomics approaches.
- Identify and reconstruct the corresponding biochemical pathways.
- Manipulate those pathways in animal models and human induced pluripotent stem (IPS) cells.
- Design drugs and intrabodies to target the main pathways involved in the disease etiology.
More information can be found on the AgedBrainSYSBIO website.