The long journey to a Systems Biology of neuronal function.

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TitleThe long journey to a Systems Biology of neuronal function.
Publication TypeJournal Article
Year of Publication2007
AuthorsLe Novère, N
JournalBMC Syst Biol
Volume1
Pagination28
Date Published2007
ISSN1752-0509
KeywordsBrain, Computer Simulation, History, 20th Century, History, 21st Century, Models, Neurological, Neurons, Systems Biology
Abstract

<p>Computational neurobiology was born over half a century ago, and has since been consistently at the forefront of modelling in biology. The recent progress of computing power and distributed computing allows the building of models spanning several scales, from the synapse to the brain. Initially focused on electrical processes, the simulation of neuronal function now encompasses signalling pathways and ion diffusion. The flow of quantitative data generated by the "omics" approaches, alongside the progress of live imaging, allows the development of models that will also include gene regulatory networks, protein movements and cellular remodelling. A systems biology of brain functions and disorders can now be envisioned. As it did for the last half century, neuroscience can drive forward the field of systems biology.</p>

DOI10.1186/1752-0509-1-28
Alternate JournalBMC Syst Biol
PubMed ID17567903
PubMed Central IDPMC1904462