Neurological disease: are systems approaches the way forward?

lenov's picture
TitleNeurological disease: are systems approaches the way forward?
Publication TypeJournal Article
Year of Publication2008
AuthorsLe Novère, N
JournalPharmacopsychiatry
Volume41 Suppl 1
PaginationS28-31
Date Published2008 Sep
ISSN0176-3679
KeywordsGenetic Predisposition to Disease, Humans, Nervous System Diseases, Systems Biology
Abstract

<p>Most neurological diseases are multifactorial diseases, where environmental conditions combine with genetic background or somatic mutations to trigger a pathological state. In the case of Parkinson's Disease and Schizophrenia, recent research revealed that susceptibility genes coded for proteins involved at different steps of specific metabolic networks and cellular processes. Comprehension of the pathology of those diseases is therefore very likely to benefit from Systems approaches. This is also true of their symptomatology, affecting neurological systems at molecular, cellular, and microcircuit levels.</p>

DOI10.1055/s-2008-1080913
Alternate JournalPharmacopsychiatry
PubMed ID18756417