Systems modelling ageing: from single senescent cells to simple multi-cellular models

TitleSystems modelling ageing: from single senescent cells to simple multi-cellular models
Publication TypeJournal Article
Year of Publication2017
AuthorsGuimera, AMartinez, Welsh, C, Pezze, PDalle, Fullard, N, Nelson, G, Roger, MF, Przyborski, SA, Shanley, DP
JournalEssays In Biochemistry
Volume61
Issue3
Pagination369
Date Published2017/07/11
Abstract

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.mTOR, mammalian target of rapamycin; NAD, nicotinamide adenine dinucleotide; NF-kB, nuclear factor-κB; qPCR, quantitative polymerase chain reaction; ROS, reactive oxygen species; SASP, senescence-associated secretory phenotype

URLhttp://essays.biochemistry.org/content/61/3/369.abstract
Short TitleEssays Biochem