Schizophrenic: forever young?

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TitleSchizophrenic: forever young?
Publication TypeJournal Article
Year of Publication2010
AuthorsBaldi, BF, Hoyer, C, Le Novère, N
JournalGenome Med
Volume2
Issue5
Pagination32
Date Published2010
ISSN1756-994X
Abstract

<p>Schizophrenia is a multifactorial complex disease with a large impact on society. Many hypotheses have been proposed over the years to explain its causes, and genomics and functional genomic approaches may shed light on the reason behind these controversies and discrepancies. We give an overview of several approaches that have been used to identify the genetic causes and molecular phenotypes of the disease. We focus on a recent microarray analysis by Torkamani and colleagues on the evolution of regulatory networks in normal and schizophrenic brains. Combining the conclusion of that study with the prevalent hypotheses of schizophrenia, we suggest that the schizophrenic brain might resemble a juvenile brain.</p>

DOI10.1186/gm153
Alternate JournalGenome Med
PubMed ID20497602
PubMed Central IDPMC2887076