Martina Fröhlich

 

 

Martina FroehlichContact: 

Martina Froehlich
The Babraham Institute, Building B570
Babraham Research Campus
Cambridge CB22 3AT
United Kingdom
Phone + 44 (0) 1223 49 6371
Email: martina.froehlich@babraham.ac.uk email-icon1-small.png

 

About:

Martina is a postdoc with Nicolas Le Novère. Within the FP7 project SynSys she is establishing a data repository of signaling in the glutamatergic synapse, which plays an important role for learning and memory. Her pathway maps are used to analyze the structural features of the signaling network and serve as a reference for subsequent model building.

 

Education and previous employments:

Martina Fröhlich studied Bioinformatics at the Goethe-Universität in Frankfurt (Germany) after gaining expertise in biological laboratory practices during an education at Provadis/Aventis Pharma. During her PhD at the International Max Planck Research School for Computational Biology and Scientific Computing (IMPRS-CBSC) Martina was working with Prof. Edda Klipp at the Humboldt-Universität zu Berlin. She applied mathematical modeling to the regulation of water and ion transport processes in yeast and kidney cells. She collaborated with researchers from the Marie Curie Training Network in Aquaglyceroporin research and from the ERA-NET project SysMo Translucent. Her theoretical work included generation of ODE-based models as well as their analysis with time-dependent sensitivity analysis and drug target identification. In addition she performed experiments on kidney cell lines in the laboratory of Prof. Peter Deen (Radboud University, Nijmegen, The Netherlands).

 

Publications:

M. Fröhlich, P. M. T. Deen and E. Klipp, A Systems Biology Approach: Modelling of Aquaporin-2 Trafficking, Genome Inform. 2010;24:42-55. PMID: 22081588 Preprint Version Supplementary Material

Szymon Stoma, Martina Fröhlich, Susanne Gerber, Edda Klipp, STSE: Spatio-Temporal Simulation Environment Dedicated to Biology, BMC Bioinformatics 2011;12:126. PMID: 21527030

Martina Fröhlich, Susanne Gerber, Hella Lichtenberg-Fraté , Jost Ludwig, Sergey Shabala, and Edda Klipp, A basic thermodynamic model of cation homeostasis in the yeast, Saccharomyces cerevisiae, manuscript in preparation.

Computational and experimental investigation of the mechanisms involved in cellular water transport and (cat)ion homeostasis. PhD Thesis, Humboldt Universitaet zu Berlin, 2012 

 

Selected talks and presentations: 

09/2013            "Building and Annotationg a Knowledge Repository of Synaptic Signalling", 14th International Conference on Systems Biology, Copenhagen, Denmark (Poster presentation) 

09/2012            "Mathematical Models of Aquaporin-2 Trafficking in Rat and Canine Kidney Cells", German Conference on Bioinformatics, Satellite Workshop: Organ-oriented Systems Biology (Invited oral presentation)

07/2010           "A Systems Biology Approach: Modelling of Aquaporin-2 Trafficking", The Tenth Annual International Workshop on Bioinformatics and Systems Biology, Kyoto, Japan (Oral presentation)

 

Other activities: Martina is associated with St John's College, Cambridge. In addition she is a member of the Babraham Institute's Postdoc Committee, one of the PdOC representatives for the Babraham Institute and is organizing regular Postdoc Coffee Events.