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GLUr2rano  rat glutamate receptor GLUR2 subunit

Organism Rattus norvegicus
Date of entry creation: 02/JUL/1999 Date of last modification: 05/JUL/2001
Accession codes for other databases DDBJ|EMBL|Genbank: 85035
DDBJ|EMBL|Genbank: M38061
SWISS-PROT: P19491
  • Boulter,J., Hollmann,M., O'Shea-Greenfield,A., Hartley,M., Deneris,E., Maron,C. and Heinemann,S. Molecular cloning and functional expression of Glutamate receptor subunit genes. Science 249, 1033-1037 (1990)
  • Sommer,B., Keinanen,K., Verdoorn,T.A., Wisden,W., Burnashev,N., Herb,A., Kohler,M., Takagi,T., Sakmann,B. and Seeburg,P.H. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS Science 249 (4976), 1580-1585 (1990)
  • Seeburg,P.H. Unpublished (1990)
  • Keinnen,K., Wisden,W., Sommer,B., Werner,P., Herb,A., Verdoorn,T., Sakmann,B. and Seeburg,P.H. A family of AMPA-selective glutamate receptors Science 249, 556-560 (1990).
  • Kohler,M., Kornau,H.C. and Seeburg,P.H. The organization of the gene for the functionally dominant alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluR-B. J. Biol. Chem. 269 (26), 17367-17370 (1994)
  • Seeburg,P.H. Direct Submission (28-APR-1994) Peter H. Seeburg, Center for Molecular Biology (ZMBH), University of Heidelberg, Germany, INF 282, Heidelberg, D-69120, Germany
  • Seeburg,P.H. Direct Submission (13-AUG-1990)
  • Schneider,N.A. Direct Submission (29-AUG-1990) Schneider N.A., Howard Hughes Medical Physicians and Surgeons, Columbia University, New York NY 10032, USA.
  • Nakanishi,N., Shneider,N.A. and Axel,R. A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron 5 (5), 569-581 (1990)
General notes
strain = Sprague-Dawley
Sequences
transcript Note: Boulter et al (longer than Keinnen et al.)
FASTA: GLUr2rano-flop.cfa EMBL: GLUr2rano-flop.cem Genbank: GLUr2rano-flop.cgb
transcript Note: Sommer et al. (longer than Nakanishi et al.)
FASTA: GLUr2rano-flip.cfa EMBL: GLUr2rano-flip.cem Genbank: GLUr2rano-flip.cgb
protein
FASTA: GLUr2rano-flip.pfa EMBL: GLUr2rano-flip.pem Genbank: GLUr2rano-flip.pgb
protein
FASTA: GLUr2rano-flop.pfa EMBL: GLUr2rano-flop.pem Genbank: GLUr2rano-flop.pgb
Structures
Structure of a glutamate receptor ligand binding core (glur2) complexed with kainate
  • Amstrong N., Sun Y., Chen G.-Q., Gouaux E. (1998). Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 395 : 913-917.
1GR2.pdb: [ Download] [ View]
Crystal structure of the glur2 ligand binding core in complex with glutamate at 1.9 A resolution
  • N. Armstrong, E.Gouaux. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the glur2 ligand binding core. Neuron, 28:165 (2000)
1FTJ.pdb: [ Download] [ View]
Crystal structure of the glur2 ligand binding core (S1S2j) in complex with kainate at 1.6 a resolution
  • N. Armstrong, E.Gouaux. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the glur2 ligand binding core. Neuron, 28:165 (2000)
1FTK.pdb: [ Download] [ View]
Crystal structure of the glur2 ligand binding core (S1S2IJ) in complex with the antagonist DNQX at 1.8 a resolution
  • N. Armstrong, E.Gouaux. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the glur2 ligand binding core. Neuron, 28:165 (2000)
1FTL.pdb: [ Download] [ View]
Crystal structure of the glur2 ligand binding core (S1S2IJ) in complex with ampa at 1.7 resolution
  • N. Armstrong, E.Gouaux. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the glur2 ligand binding core. Neuron, 28:165 (2000)
1FTM.pdb: [ Download] [ View]
Crystal structure of the glur2 ligand binding core (S1S2IJ) in the apo state at 2.0 a resolution
  • N. Armstrong, E.Gouaux. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the glur2 ligand binding core. Neuron, 28:165 (2000)
1FTO.pdb: [ Download] [ View]
Crystal structure of the glur2 ligand binding core (S1S2IJ) in complex with kainate at 2.0 a resolution
  • N. Armstrong, E.Gouaux. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the glur2 ligand binding core. Neuron, 28:165 (2000)
1FW0.pdb: [ Download] [ View]
Crystal structure of the non-desensitizing glur2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 A resolution
  • Y.Sun,R.Olson,M.Horning,N.Armstrong,M.Mayer, E.Gouaux. Mechanism of glutamate receptor desensitization. Nature, 417: 245 (2002)
1LB8.pdb: [ Download] [ View]
Crystal structure of the non-desensitizing glur2 ligand binding core mutant (S1S2J-L483Y) in complex with antagonist DNQX at 2.3 A resolution
  • Y.Sun,R.Olson,M.Horning,N.Armstrong,M.Mayer, E.Gouaux. Mechanism of glutamate receptor desensitization. Nature, 417: 245 (2002)
1LB9.pdb: [ Download] [ View]
Crystal structure of the glur2 ligand binding domain mutant (S1S2J-N754D) in complex with kainate at 2.1 A resolution
  • Y.Sun,R.Olson,M.Horning,N.Armstrong,M.Mayer, E.Gouaux. Mechanism of glutamate receptor desensitization. Nature, 417: 245 (2002)
1LBB.pdb: [ Download] [ View]
Crystal structure of glur2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution
  • Y.Sun,R.Olson,M.Horning,N.Armstrong,M.Mayer, E.Gouaux. Mechanism of glutamate receptor desensitization. Nature, 417: 245 (2002)
1LBC.pdb: [ Download] [ View]
Miscellanea
Phylogenetic analyses
All the information under the LGICdb format (the file is unparsable by HTML browsers. You can visualize it with the "View Source" tool of your browser.)

  Citation

Nicolas Le Novère and Jean-Pierre Changeux (1999). The Ligand-Gated Ion Channel database. Nucleic Acid Research, 27 : 340-342
( PDF version)

Last modification: Mon Jun 25 12:43:58 2007 GMT | Nicolas Le Novère

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