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GLUnr2bhosa  human glutamate receptor NMDAR2B subunit

Organism Homo sapiens
Date of entry creation: 28/AUG/1999 Date of last modification: 05/SEP/2002
Accession codes for other databases DDBJ|EMBL|Genbank: U11287
DDBJ|EMBL|Genbank: U28861
DDBJ|EMBL|Genbank: U90278
  • Adams,S.L., Foldes,R.L. and Kamboj,R.K. Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein. Biochim. Biophys. Acta 1260 (1), 105-108 (1995)
  • Hess,S.D., Daggett,L.P., Crona,J., Deal,C., Lu,C.C., Urrutia,A., Chavez-Noriega,L., Ellis,S.B., Johnson,E.C. and Velicelebi,G. Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 278 (2), 808-816 (1996)
  • Daggett,L.P. Direct Submission. Submitted (20-FEB-1997) SIBIA Neurosciences, Inc., 505 Coast Blvd., South, La Jolla, CA 92037, USA
  • Mandich,P., Schito,A.M., Bellone,E., Antonacci,R., Finelli,P., Rocchi,M. and Ajmar,F. Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. Genomics 22, 216-218 (1994)
  • Mandich,P., Schito,A.M. and Ajmar,F. Direct Submission (09-JUN-1995) Paola Mandich, Inst. of Biology and Genetics, Univ. of Genoa, Viale Benedetto XV, 6, Genova 16132, Italy
General notes

protein sequence initially provided by Wladimir Saudek

I can't decide between the two variants. If anybody can help ...

U11287 (Adams et al. 1995):

U90278 (Hess et al. 1996):

Sequences
transcript Note:

misc_difference 1430, gene="hNR3", note="hNR3-2", replace="a"

misc_difference 2874, gene="hNR3", note="hNR3-3", replace="t"

3'UTR 4666..>5969

FASTA: GLUnr2bhosa-U11287.cfa EMBL: GLUnr2bhosa-U11287.cem Genbank: GLUnr2bhosa-U11287.cgb
transcript Note:

sig_peptide 210..287, mat_peptide 288..4661

FASTA: GLUnr2bhosa-U90278.cfa EMBL: GLUnr2bhosa-U90278.cem Genbank: GLUnr2bhosa-U90278.cgb
protein
FASTA: GLUnr2bhosa-U90278.pfa EMBL: GLUnr2bhosa-U90278.pem Genbank: GLUnr2bhosa-U90278.pgb
protein
FASTA: GLUnr2bhosa-U11287.pfa EMBL: GLUnr2bhosa-U11287.pem Genbank: GLUnr2bhosa-U11287.pgb
Structures
Theoretical model of glutamate binding site of NMDA receptor in closed form
  • I.G. Tikhonova, I.I. Baskin, V.A. Palyulin, N.S.Zefirov, S.O. Bachurin. Structural basis for understanding structure-activity relashionships for the glutamate binding site of the NMDA receptor. J. Med. Chem. 45: 3836 (2002)
1S11.pdb: [ Download] [ View]
Theoretical model of glutamate binding site of NMDA receptor in opened form
  • I.G. Tikhonova, I.I. Baskin, V.A. Palyulin, N.S.Zefirov, S.O. Bachurin. Structural basis for understanding structure-activity relashionships for the glutamate binding site of the NMDA receptor. J. Med. Chem. 45: 3836 (2002)
1S2S.pdb: [ Download] [ View]
Miscellanea
Phylogenetic analyses
All the information under the LGICdb format (the file is unparsable by HTML browsers. You can visualize it with the "View Source" tool of your browser.)

  Citation

Nicolas Le Novère and Jean-Pierre Changeux (1999). The Ligand-Gated Ion Channel database. Nucleic Acid Research, 27 : 340-342
( PDF version)

Last modification: Mon Jun 25 12:43:55 2007 GMT | Nicolas Le Novère

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