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ACHb2rano  rat nicotinic acetylcholine receptor β2 subunit

Organism Rattus norvegicus
Date of entry creation: 1999-05-09T00:00:00 Date of last modification: 2004-11-19T23:14:58
Accession codes for other databases DDBJ|EMBL|Genbank: L31622
Locus Chr 2 q34
  • Boulter,J., Connolly,J., Deneris,E.S., Goldman,D.J., Heinemann,S.F. and Patrick,J. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proc. Natl. Acad. Sci. U.S.A. 84, 7763-7767 (1987)
  • Deneris E.S., Connolly J.G., Boulter J., Wada E., Wada K., Swanson L.W., Patrick J., Heinemann S.F.; "Primary structure and expression of beta 2: a novel subunit of neuronal nicotinic acetylcholine receptors."; Neuron 1:45-54(1988).
General notes

The sequences were corrected on the basis of new sequencing by Jerome Sallette. Three bases were introduced in the transcript, resulting into the change EAV to AGAL in the cytoplasmic domain. The new sequence is identical to the human one.

Sequences
genomic
Accession codes for other databases Ensembl: ENSRNOG00000020778
FASTA: ACHb2rano.gfa EMBL: ACHb2rano.gem Genbank: ACHb2rano.ggb
transcript
Accession codes for other databases Ensembl: ENSRNOT00000028200
FASTA: ACHb2rano.cfa EMBL: ACHb2rano.cem Genbank: ACHb2rano.cgb
protein
Accession codes for other databases UniProt: ENSRNOP00000028200
UniProt: ACHN_RAT
FASTA: ACHb2rano.pfa EMBL: ACHb2rano.pem Genbank: ACHb2rano.pgb
Structures
Model of rat (a4)2(b2)3 receptor
  • Le Novere N., Grutter T., Changeux J.-P. (2002). Proc. Natl. Acad. Sci. USA, 99: 3210-3215.
a4b2rn.pdb: [ Download] [ View]
Model of Rat (a3)2(b2)3 receptor
  • Le Novere N. (2002). Unpublished
a3b2rr.pdb: [ Download] [ View]
Epibatidine bound to chick Rat a3b2 binding site
  • Sallette J., Bohler S., Benoit P., Soudant M., Pons S., Le Novere N., Changeux J.-P., Corringer P.-J. (2004) An extracellular microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine. Journal of Biological Chemistry, 279: 18767-18775.
a3b2rr_epi.pdb: [ Download] [ View]
Miscellanea
Phylogenetic analyses
All the information under the LGICdb format (the file is unparsable by HTML browsers. You can visualize it with the "View Source" tool of your browser.)

  Citation

Nicolas Le Novère and Jean-Pierre Changeux (1999). The Ligand-Gated Ion Channel database. Nucleic Acid Research, 27 : 340-342
( PDF version)

Last modification: Mon Jun 25 12:42:07 2007 GMT | Nicolas Le Novère

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